Neutral haplotypes for DMT1

Good evening, and thanks, to all the foreros and foreras, for their participation in the, since it is my head book many nights and where I have learned the most about diabetes since my son debuted a year ago ,,,, has 17Years and is diagnosed as DMT1, it has the 4 positive antibodies, although the anti -3They have done this year, the issue is that they have now given the result of haplotypes, and it is HLA-DRB1 15.16.and HLA-DQB1 05 ,, These haplotypes are considered neutral for DMT1, my question is the following, someone with DMT1 has these haplotypes? since they are rare in diabetes I think, for what I have read ....

Good morning @JBF I'm glad to read that you have this forum among your night readings, if you want to give it an additional plus, I strongly recommend that you give a look at the book too !!: Smiley:

Back to your question, I think it is the first time I have read about haplotypes, in fact, I have looked for information that I share below.

Haplootypes are sets of genetic variations that tend to inherit together due to their proximity in the genome.These variations may include single nucleotide polymorphisms, insertions or deletions in DNA¹ ( Link are important to understand genetic inheritance and predisposition to certain diseases² ( Link

In the case of diabetes, especially type 1 diabetes, it has been identified that certain haplotypes can increase the risk of developing this disease² ( Link is because haplotypes can contain genetic variants that affect the function of the immune system, which can lead to greater susceptibility to diabetes² ( Link

Here are some references on the subject:

(1) Human haplotypes: definition & examples - Studysmarter. Link
(2) Haplootype: What is it?Why is it important?- Unilabs. Link
(3) Haplootype: What is it?Why is it important?- Unilabs. Link
(4) Haplootype - CROM - Institute of Human Cytogenetics. Link

I would like to be able to give you information about my experience, but at least, I don't have, to see if any other forero throws us a hand.:)

Thanks Fer, you've already sent me duties for tonight ha ha.,
I will buy the book, thanks, but to see.If there is someone with experience, about this, since it is an analysis that they do to debut ... or a few months later. I think that almost all DMT1 ,,

I will love that once read I give me feedback, if you think it is useful for your case, if your son reads it that seems to him, etc ... thanks @jbf !!!

@JBF, because they must be the most recent genetic analyzes, because until recently antibodies were analyzed.
I don't know how to say, but I'm very happy that you are moving forward in diabetes genetics.

Well, I had never heard of haplotypes

They made me peptide C the year I debuted, 3 years later and never again in 9 years.

Hello.I hadn't heard about this either.They made me an antibody and peptide analytics when I debuted (in October 2019), but never again.