Mutation of the SIRT1 gene can cause Development Type 1 Diabetes

I have found this information that can be interesting but is published in a magazine of a foundation for disabled attention in a PDF file that is necessary to download to read it.The address is: http: //www.fundacionafim.org/index.php? Section = Magazine
It is on page 15 of said document.
There I leave it in case it serves someone.

A single mutation in the SIRT1 gene can cause type 1 diabetes. This finding, which is published in Cell Press, could open new treatment paths for diabetes, but also for other autoimmune diseases.

In type 1 diabetes, the immune system destroys cells that produce insulin in the pancreas, but its exact cause is not defined.The study reveals that a single mutation in the "genetic longevity" of SIRT1 can cause type 1 diabetes in humans.

The author of the work, Marc Donath, of the University Hospital of Basel (Switzerland), explains that type 1 diabetes is a chronic and potentially deadly disease that is usually diagnosed in young people;It occurs because the beta cells of the pancreas do not produce enough insulin hormone, which causes high blood sugar levels.Animal studies have shown that a gene called SIRT1, "famous" for its role in promoting longevity and protection against age -related diseases, also regulates insulin secretion and the development of autoimmune diseases and that itsActivation can protect against type 1 diabetes. But so far, its role of Sirt1 in autoimmunity and in human diseases was unknown.

Affected family

In the new study, Donath and his team described a family with a mutation in the SIRT1 gene.The five affected members had developed an autoimmune disorder and four of them type 1 diabetes. Thanks to the use of a combination of gene sequencing techniques, the researchers identified a mutation, previously not documented, which caused a replacement of amino acids in the SIRT1 protein.In addition, the researchers saw that the inactivation of the SIRT1 gene in mice caused the destruction of the insulin producing region of the pancreas, which produced an elevation of blood sugar levels.

According to Donath, "the identification of a gene that causes type 1 diabetes should allow us to understand the mechanism responsible for the disease and can open new treatment options."Its next step, it advances, is to create a transgenic mouse carrier of the mutation with the hope of developing an animal model of human diabetes.

This is to complete the information, thank you very much for it, although I only found it by chance since my brother attends the AFIM Foundation that carries the article published in its last magazine.

Enchanted to be able to do it! There is nothing like being able to read "of the pull" all the information on a subject.
= D> = D> = D>

Almost 40 % of patients are not aware of their risk of diabetes
Should doctors talk to patients more frequently about their diabetes risk factors?...

A recent survey conducted by the American Diabetes Association involved 1,400 patients and 600 health professionals to determine their perception of their risk of developing diabetes.According to the results, 40% of those who were at a higheBlood and other diabetic risk factors.Only 25 % of those who have the greatest risk of developing diabetes were aware of their susceptibility.

According to the survey, most patients knew that lifestyle factors to change in order to help avoid the development of diabetes, that is, diet and exercise.The problem may determine that 80 % of patients who were at risk for diabetes and should change their lifestyle felt they were currently in good or excellent health.

These findings indicate that doctors may need to be more open with patients at risk of diabetes ensuring that they are aware of their risks, and what should be done to stop them.

Practice pearls:
Forty percent of the patients surveyed who were at a greater risk of developing diabetes felt that they were not at risk.
Less than half of the patients surveyed regularly informed of their doctor about the risks of developing diabetes.
Eight percent of patients who were currently at a greater risk of developing diabetes reported to be of good or excellent health.
American Diabetes Association, December 2013
Automatic Google translation without correcting