INS-PBA-F.It looks like a series of acronyms or an access password to email, but it is much more.We talk about one of the last steps towards greater comfort in those patients suffering from type 1 diabetes. This 'intelligent' insulin created by researchers from the University of Utah (USA), whose duration per dose exceeds 14 hours and has obtained resultsPositive when trying in mice, it has the peculiarity of self -acting when blood sugar rises.
If the usefulness of this creation is definitively confirmed, two of the main problems of patients with this variant of the disease would be put up: the constant monitoring of the amount of blood sugar and knowing when and how much insulin should be injected.
Human tests will not begin up to two years
INS-PBA-F acts faster and better in the reduction of blood sugar than the prolonged action insulin, marketed as' Levimir ', according to the results of the study, which are published in the early edition of' Proceedings of theNational Academy of Sciences' (PNAS).In fact, speed and kinetics to reach safe levels of blood glucose are identical in diabetic mouse models treated with ins-pba-f and in healthy mice whose blood sugar is regulated by its own insulin.
"This is an important advance in insulin therapy," said one of the authors of the project and researcher and assistant biochemistry at the University of Utah, Danny Chou."Our insulin derivative seems to control blood sugar better than anything available for diabetes patients at this time," added the expert, who will continue to evaluate long-term safety and the effectiveness of INS-PBA-Fb.The insulin derivative could reach phase 1 of clinical tests in humans in a period of between two and five years.
The main symptom of diabetes is the inappropriate control of blood sugar, a deficit that is more pronounced in type 1 diabetes, which develops when beta cells of insulin of the pancreas are destroyed.Without insulin, there is no way to transport sugar out of blood and cells, where it is used to obtain energy.DM1 patients depend on daily insulin injections to survive.
Despite the advances in the treatment of diabetes, such as insulin pumps and the development of four types of insulin, patients must still manually adjust the amount of insulin administered.The blood glucose levels vary greatly depending on a series of factors such as what is eaten and if exercised.
A glucose -sensitive insulin that is automatically activated when blood sugar levels are high would eliminate the need for additional insulin reinforcements and reduce the dangers associated with an incorrect dosage.
Diabetes Tipo 1 desde 1.998 | FreeStyle Libre 3 | Ypsomed mylife YpsoPump + CamAPS FX | Sin complicaciones. Miembro del equipo de moderación del foro.
Autor de Vivir con Diabetes: El poder de la comunidad online, parte de los ingresos se destinan a financiar el foro de diabetes y mantener la comunidad online activa.
As someone from the forum said recently, who was a mouse!Everything is worth and heals them!
Of course an insulin like this would be an almost-corner.
Padre de Andrés, 17 años. Debut: septiembre de 2011.
Levemir (30ud. mañana y 24ud. noche) y Novorapid (en desayuno, comida, merienda y cena 40ud aprox - 24HC/día).
Medidor continuo DEXCOM G4 desde julio 2014
Hemo: 6.2 (Sept. 2013), 7.0 (Dic. 2013), 6.9 (Marzo 2014), 6,6 (Junio 2014), 6,7 (Sept. 2014), 7,0 (Dic. 2014), 7,7 (Mar 2015), 6,9 (Jul. 2015), 7,0 (Sept 2015), 7,4 (Dic 2015), 6,8 (Mar 2016), 6,6 (Julio 2016), 6,8 (Octubre2016)... 7,0 (Mar 2018)
With an insulin thus diabetes would resemble what most non -diabetic people believe it is diabetes.
But in this article they do not explain anything, either how it works, or what components it carries, or anything.:-?
En 1922 descubrieron la insulina, en 1930 la insulina lenta. ¿Que c*** han hecho desde entonces?
How strange, I have found news of an identical discovery published yesterday but that is not at the University of Utah if not at MIT.And this one explains how it works:
Link
Researchers at mit Havelped to New Form of Treatment that not only circulations for a long period of time, but is only Activated When Blood Sugar Levels Get Too High.This Would provides more efficient method of dealing with glucose spikes over extended periods of time.
To create the new, Glucose-Reponsive Treatment, The Rebecchers Made Two Modifications.Firstly, in Order to Reure that the Engineered Hormone Stays in the Bloodstream for the Required Length of Time, to Hydrophobic Molecule Known as an aliphatic domain was added.It’s not known for certainty the chain of fatty molecules prolong the molecule’s lifespan in the bloodstream, though it’s though that like it may bind to proteins, preventing the insulin from Tackling sugar molecules.
Secondly, Refeded PBA Reviews - A Chemical Group That Reversibly Binds to Glucose, Thus Bringing It Into Contact With The Insulin When High Levels of Sugar Present presented themselves.The Team Created Four Different Variants of the Engineered Molecule, Each Containing PBA with A Different Chemical Modification, Such As Fluorine Or nitrogen ...
En 1922 descubrieron la insulina, en 1930 la insulina lenta. ¿Que c*** han hecho desde entonces?
If you are investigating in the MIT, you have to arrive.
Hija de 35 años , diabética desde los 5. Glico: normalmente de 6 , pero 6,7 la última ( 6,2 marcaba el Free)
Fiasp: 4- 4- 3 Toujeo: 20
It is hopeful.A line of research that I did not know.It is good that there are many lines and different.Something will take.
Padre de Jesús. Bomba insulina y dexcom g4 share. Debut con 18 meses....ya con 7 añitos...Hemo entorno a 7....y mucha lucha diaria.....ya sabéis..poco dormir y bastantes miedos....pero mi niño es feliz luego yo también.
