Combination of independent roads of hyperglycemia
Describe the mechanisms of sodium tungstate in diabetes
A study coordinated by Jordi Altirriba, of the Diabetes and Obesity Department of the Clinical IDIBAPS-Hospital of Barcelona, has described that the MAPK gene signaling is key in the proliferation of beta cells that induces sodium tungstate in diabetics.
Karla Pieck Islands.Barcelona - Friday, October 9, 2009 - Updated at 00: 00h.
The antidiabetic effects of sodium tungstate are well known to the scientific community, but so far the molecular mechanisms involved in this process were unknown, so the Diabetes and Obesity Department group of the Institute of Biomedical Research August Pi I Sunyer (Idibaps) and the Clinical Hospital of Barcelona has investigated the processes that explain that this substance improves pancreatic plasticity.
The results of a study that is published in the electronic edition of BMC Genomics conclude that sodium tungstate improves the function of the pancreas through a combination of independent pathways of hyperglycemia and through its own direct and indirect effects.
Jordi Altirriba, the first signatory of the study, has explained to DM that the MAPK gene path plays a very important role in increasing the proliferation of beta cells, induced by this anti -diabetic agent.
The researchers have worked with animal models of which diabetes have been induced by meanspartial regeneration of the endocrine pancreas and an improvement of the exocrine pancreas.
"Then we analyze the pancreas of these animals and observe the genetic bases to determine which genes could be involved in the regeneration we observe after administering this substance."
Independent
In addition, in an animal control group, which has been subjected to other mechanisms to reduce blood glucose levels, it has been observed that genes that are modified due to sodium tungstate are not affected by the other way"Therefore, we deduce that genes are independent of the animal's status of blood glucose."
The Map Cinases route, specifically that of the RKIP Gen, is one of the lines of research that focus the attention of these scientists, who have already projected to design new works that provide more clues about the effects of this antidiabetic.
Altirriba has detailed that "when we treat some cells with the serum of the animals the road of the map cinases is modified and when we inhibit this pathendocrine decreases. "
New ways to explore
The findings of the team led by Jordi Altirriba in the Clinical IDIBAPS-Hospital of Barcelona do not have a direct clinical application, but open the door to the design of new research works aimed at determining the implications of the genes and signaling routes that are relatedwith the antidiabetic effects of sodium tungstate.These researchers have already launched an essay that intends to study the RKIP gene in depth with the aim of knowing exactly their mechanisms of action in the diabetics pancreas.In the medical literature there is a study in this direction, "but we want to go further," according to the principal investigator to DM.
dm, is a medical newspaper ... No, diabetes mellitus: d
