Bad control glymia in diabetics explains its lower defense capacity
This work has demonstrated the relationship between the low phagocyte activity of macrophages (organism defense cells) and the bad glucose control of patients with type II diabetes, VHIR reported through a press release.
Although it is known that patients of this type of diabetes (of adults and the most frequent) are more risk of infections, the causes are not known, so this research was based on a hypothesis about the role of macrophages and their contribution inControl of infections.
The investigation, in which the cyber of diabetes and associated metabolic diseases (CIBERDEM) has also participated, has studied the phagocytic activity of these macrophages, that is, their ability to eliminate the germs detected in the body.
This activity has been measured in patients suffering from type II diabetes and had bad metabolic control, specifically those with a glycosylated hemoglobin (HBA1) greater than 8%, significant of a bad control of blood sugar levels in a sustained way during thelast 3 months.
These patients were admitted for 5 days to optimize glycemia control and the phagocyte activity of macrophages were measured by meansnormalized
The results were clear.GiveImmunity and in the control of infections, explains Dr. Rafael Simó, head of the Diabetes and Metabolism Research Group of VHIR.
Rafael Simó and Dr. Jordi Périz, responsible for the stem and cancer laboratory of the Biomedical Research Unit of the same VHIR, are responsible for this pioneering study, which has been published in the latest edition of PLOS One magazine.
Although the study focuses on determining the levels of macrophage activity before and after the metabolic control of diabetics, the role that the phagocytic activity of these macrophages could have could be related to the greatest risk of infection sufferedDiabetics, especially with hospital infections.
Diabetics are also more likely to suffer infected pneumonies and ulcers, and frequently suffer more complications.
An example occurred during the Epidemic A (H1N1), since diabetes patients had three times more risk of income for this cause or that a diabetic multiplies by four the risk of admission to the ICU, due to complications, during ahospital stay.
Sometimes, during diabetic income, and before a serious pathology, normalize sugar levels is for the authors of the study "a priority".
In this sense, this study provides a fact that could contribute to a change: metabolic control could impact directly and in the short term on improving diabetics against an infection.EFE
