Spanish scientists manage to stop type 1 diabetes in mice reeducing their immune system
The work identifies "molecular mechanisms" that give rise to type 1 diabetes
A single dose of vaccine for "life" protection is sufficient
In the next three years an applicable technique in humans will be investigated
Rtve.es / agencies
A team of researchers from the Germans Trias I Pujol de Badalona (Barcelona) hospital has managed to stop the development of type 1 diabetes in laboratory mice, which through 'in vitro' techniques have managed to "re -educate the immune system."
The researcher of the diabetes immunology group Marta Vives, which Europa Press cites, explained that the work has allowed "to identify the molecular mechanisms" that give rise to type 1 diabetes and also to its eventual vaccination, so thatHe has ventured that these results could move to humans.
The work, published by the magazine 'Plos One', has had the collaboration of the Vall d'Hebron Institut de Recerca (VHIR) and the Institut de Recerca Biomèdica of the University of Lleida (UDLL), with the financing of the Institute of HealthCarlos III.
A lifetime dose
Catalan researchers have managed to extract dendritic cells from mice and modify them so that, once reintroduced, they slow the destruction of insulin producing cells, where is the origin of type 1 diabetes.
The experiment has been done with a type of laboratory mouse used worldwide because in 70% of cases develop this type of diabetes naturally, and scientists have achieved that, once the treatment is applied, this figure is reducedUp to 20%, Vives said.
Type 1 diabetes is an autoimmune disease that is triggered because the body begins to destroy the cells that produce insulin, and the team of the germans trias and pujol has verified that the "reprogramming" serves to reverse this trend in the fifty mice in theThat has been tested.
Researchers have proven that a single dose of "vaccine" is sufficient so that the acquired protection is for life, and Vives has considered that, in 20% of cases that have no apparent healing, the solution could be to adjust thedose, the pattern or the moment in which the therapy is applied.
Application in humans
Vives has recalled that humans also present markers in the blood serum that indicate the possibility of suffering from type 1 diabetes, and although "they are not 100%reliable" because they appear when the autoimmune attack has already been triggered, they could serve as a marker forDesign a similar healing in people.
In fact, the researcher has considered that the molecular mechanism that triggers diabetes in mice and humans "would be very similar", so the reeducation of the immune system could also be an effective therapeutic pathway.
The current problem focuses that, if in the case of a 30 grams mouse it is necessary to reprogram 1 million cells, in the case of a human it would be necessary to reformulate millions of cells, which does the unfeasible process.
"We are working on a strategy to improve these aspects," Vives summarized, since it is expected that during the next three years a strategy applicable to humans will be investigated that, to a large extent, goes through designing a more efficient and standardizable process.
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