United Kingdom researchers use a method that provides new information about the causes of the disease.
Researchers at the Center for Clinical Sciences of the Medical Research Council of London, in the United Kingdom, have identified a network of genes and regulatory regions that could contribute to the risk of developing type 1 diabetes. The results of the work are published in the Nature magazine.
The wide genome association studies have revealed a variety of genes linked to type 1 diabetes, but in current work, researchers have used a method that provides new information about the causes of this disease.
The analysis combines various genetic methods that involve studies of genetic expression and genetic data of rat and humans to reveal DNA regions that control the expression of a group of genes associated with T1D, factor 7 interferon regulator (IRF7), which directs theInflammatory Network.The innate viral response mechanism and immune cells called macrophages are also involved in T1D.
The study is also of interest because it successfully combines genes of genes and variations in the DNA sequence and underlines the fact that the regulatory regions that disturb biological networks can have an important role in the risk of disease.