Hello everyone!
I share a news that has gone around the world and that fills the entire community of people with diabetes with hope, as well as our families and friends:
👉 Historical milestone for scientists: they get people with type 1 diabetes to generate insulin without medication.
Yes, you have read well.The cure for type 1 diabetes seems to be, finally, closer.
What is this progress?
The study, developed by Sana Biotechnology in collaboration with the Uppsala University Hospital (Sweden), has made patients with type 1 diabetes manage to maintain insulin production for six months, without insulin injections or immunosuppressive treatments (drugs that are usually used to avoid rejection in transplants).
This has been achieved by modified pancreatic islet cell transplant (UP421), which have been designed to evade both the immune rejection of the receiver and the autoimmune attack that triggered type 1 diabetes first.
Dr. Per -la Carlsson, main researcher of the study, explained:"As an endocrinologist who has dedicated his career to improve the results of patients with type 1 diabetes, I am pleased to share these exciting results. We believe that this six -month update continues to suggest that a functional cure for type 1 diabetes is possible without immunosuppression."
What does this mean in practical terms?
Transplanted cells not only survive in the patient's body, but continue to produce insulin naturally.This is demonstrated by measurement of the blood C in the blood (a clear marker of the endogenous production of insulin) and through mixed meter tolerance tests that confirm that insulin production increases in response to food intake.
Until now, pancreatic islet transplants required chronic immunosuppression to avoid rejection, which greatly limited their use (due to the serious side effects of these drugs).In addition, they did not solve the background cause: the autoimmune attack that destroys beta cells.
With this new technology, called Hip (Hypoimmune Platform), healthy Biotechnology has managed to design cells capable of “hiding” from the immune system, avoiding both the donor's rejection and the autoimmune attack.
Current state of the study
⚠️ It is important to be realistic: it is a study still in the evaluation phase, focused on demonstrating the long -term viability of the transplant.For now, the first six months have been an unprecedented success.
Researchers continue to monitor patients to see if this effect is maintained beyond six months, if there are adverse reactions or unforeseen problems.
But for the first time it has been shown that it is possible that a person with type 1 diabetes produces his own insulin, without medication or immunosuppression.
Impact for all of us
I don't know you, but I am very excited to read news like this.
Those of us who live with diabetes (or we have a loved one who suffers from it) We know very well how hard the constant self -control, hypos, hypers, carbohydrate counting, insulin ... all day, every day, every day.
Such a solution - a cell transplant that returns the ability to produce insulin naturally and safely - would radically change our lives.
Although it is not yet something available for everyone, nor immediate, this news gives us real hope.We are no longer talking about vague promises, but about concrete results in humans, with medium -term monitoring and without serious adverse effects.
What can we do in the meantime?
While we hope that these advances are consolidated and become accessible therapies, there is something that remains equally important: take care, support and learn together.
In our forum we share doubts, experiences, fears and joys.And we can also help us be informed about this type of advance.
What inspires this news?
Are you optimistic or do you prefer to wait for more results?
How would your life change if you really could leave insulin?
