Metformin is for some the first treatment after the diagnosis of type 2 diabetes;for others, a traveling companion for years.We know it works, but we don't always know why it works.And that's exactly where this new study provides something very interesting.

A team of researchers from CIBER, together with the University of Barcelona and other reference centers, has identified a new regulatory axis that helps explain part of the antidiabetic effects of metformin.Simply put: it does not act alone or through a single pathway, but rather it coordinates several key pieces of the metabolism.


What exactly have they discovered?

Until now we knew that metformin activates a fundamental enzyme called AMPK, something like the “energy sensor” of our cells.It had also been observed to increase the levels of GDF15, a molecule related to reduced appetite, weight loss and better glucose control.

What is new about this study is that it places the PPARβ/δ receptor at the center of this story.Researchers have seen that, without this receptor, metformin loses much of its effectiveness in animal models:

  • Less improvement in glucose tolerance
  • Activates less AMPK
  • Does not correctly increase GDF15 levels

That is, PPARβ/δ acts as a key switch for metformin to deploy its full metabolic potential.


Why is this relevant to us?

Because it reminds us of something very important: not all of us respond the same to treatments.Understanding these mechanisms opens the door to a more personalized type 2 diabetes, where in the future treatment can be better adjusted according to how our body responds.

In addition, it reinforces an idea that many people in the forum already share from experience: metformin not only lowers glucose, it also influences weight, appetite and general energy balance.

These types of scientific advances are an example of why it is so valuable to share knowledge and experiences, not only between researchers, but also between people with diabetes, couples, families and friends.In the forum we have been doing just that for years: translating science into real life.

We continue to learn, share and move forward together.💙

Greetings,