Would you make an implant to control type 1 diabetes?

A device for the size of a small currency could drastically alter the treatment of type 1 diabetes, a chronic disease that affects millions of people and that still has no cure.

The Alessandro Grattoni and Jesus Paez-Mayorga team of the Research Institute of the Methodist Hospital in Houston, Texas, United States, has managed to incorporate islet and immunotherapy cells directly into a 3D printed device, comparable in some aspects to an artificial pancreas, and called Niche (implantable neovascularized cell homing and encapsulation).

The treatment with this device restored the healthy levels of glucose and eliminated the symptoms of type 1 diabetes in animal models for more than 150 days, while avoiding the serious adverse effects of antirreric therapy by administering immunosuppressive drugs only where the cells wereof the transplanted islets.

The Niche, created in the Nanomedicine department of the aforementioned institute, is a flat device that is placed under the skin and consists of a deposit for the islet cells and a drug tank for localized immunosuppression therapy.This is the first platform that combines direct vascularization and local immunosuppression in a single implantable device for alogenic transplantation of pancreatic islets and long -term treatment of type 1 diabetes. Direct vascularization is essential to supply nutrients and oxygenin order to maintain the viability of transplanted islets.

The Niche incorporates ports for drug recharge as necessary.During the tests, the researchers filled the drug deposits every four weeks.

The Grattoni team is already working on the adaptation of Niche technology for clinical use, including improvements such as drug recharge would only be necessary once every six months, a time long enough to make the use of technologyNiche is very practical for patients.

In addition, making the appropriate changes in the formulas or in the concentration of the drugs, the filling intervals could be extended until one a year was enough, coinciding for example with routine medical visits to supervise the patient's condition.

Grattoni and his colleagues expose the technical details of their device and the results of the tests with him in the academic magazine Nature Communications, under the title "Implantable Niche With local Immunosuppression for Islet Allotransplantation Achieves Type 1 Reversal in Rats Diabetes".(Source: Amazings NCYT)

Changing it once a year or every 6 months?Without having to click 4 or 5 times a day?
I put it without thinking.

I don't know, I don't know how much insulin produce those islets?
The same requires a concrete diet to balance the intake with what the apparatus produces.
How is it stimulated to segregate it? In what amount?
Does hypoglycemia with exercise or fasting?

A lot of unknowns yet but look good if it progresses.

Yes, of course, a living cell implant,
It sounds very good.
I hope I arrive someday.

Well, hopefully something like this came to us, but I see it still quite green ... it would also be necessary to imply exactly the "localized immunosuppression therapy."But come on, everything that is studies and advances, welcome.

Buffff would put it without thinking, moreover, I would volunteer for clinical trials 🤣🤣🤣

Clear

Why don't you study how to eliminate the antibodies we have generated, pancreas destroyers?

Of course I would try it, what is not normal is that at this point in the century technology and biomedicine have not found a less heavy way to carry diabetes ... I hope I arrive today better than tomorrow.

The "good" of this treatment is that pharmaceuticals would be a very profitable business.They would charge for the implant, for cells and medicines.And semiannually.So if it worked it is possible that if it is marketed.He would not be lost in a drawer.

ruthbia said:
Why don't you study how to eliminate the antibodies we have generated, pancreas destroyers?

This is the question.
Diabetes: To the endocrine
Multiple sclerosis: to the neurologist
Rheumatoid arthritis: to the rheumatologist
Atopic dermatitis, Areatas: to the dermatologist
Asthma: To the neumologist
Diverse allergies: to the allergologist
What do they all have in common?An immune system that does not work correctly.We are treated by the damages that the immune system causes us in each specialty according to the affected organ, but ... why is there no discipline that studies the immune system?
I feel that medicine is stagnant on this issue, they provide us with patches to live with the disease but not to solve the root problem, which are the fighter antibodies that attack our own cells.We have no hope of healing but palliative to live with the problem forever, without being able to reverse it.

Is that I believe that antibodies appear due to genetic causes, associated with viruses many times ..,
The real problem is in genes, and medicine has not yet arrived.If one day, altered genes would be rebuilt, we would already be in another dimension.

@ENSALADA That was my question to the otorrinolaringologist on Monday for chronic rhinitis + nasal polyps.I am fed up with the nasal corticosteroids for inflammation, I want the root cause to be cured.
It can operate and reduce the mucosa, but it reproduces, that is, there is no solution, and the immune failure origin.
And just goes and that makes me compared to dermatitis (which I have been born since I was born) to tell me that there is no cure, only palliative and what is there.

What I do not understand is how they do so that anti -right drugs do not leave the implant and instead can enter the blood.

@Sherpa41, so we will have to renew it every x months ...

If a baqsimi diabetes medicine that is nasal glucabon, does not cover the SS because it is expensive, as if to cover a treatment, I think we will not be in this world to see it

I just need to know what is safe for my son

You want the remedy in weeks for the DM1, wait for Elon Musk ...

_ tacker _ said:
you want the remedy in weeks for the DM1, wait for Elon Musk ...

hahahaha ... That would be a bombing !!