Michigan Medicine researchers in the United States have observed that multiple lipid biomarkers are related to the development of neuropathy in patients with type 2 diabetes. This finding opens the possibility of testing new biomarkers and developing a management more focused on patients with the condition.
The researchers examined serum samples of almost 70 members of the Indian community of the Gila River with type 2 diabetes who were done a neuropathy test 10 years later.They analyzed 435 different species of lipids, which are organic compounds composed of fats and oils.
The results published in 'Annals of Clinical and Translational Neurology' reveal that participants with high diabetic neuropathy scores had changes in lipids that reflected a deteriorated energy metabolism.
"We have the potential to test these lipid biomarkers in patients with type 2 diabetes to identify those with the greatest risk of developing peripheral neuropathy and facilitating a more focused management of these patients," explained the main author Eva L. Feldman, teacherDistinguished from James W. Albers at the UM and director of Neuronetwork for Emerging Therapies in Michigan Medicine.
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While there were differences between the basic lipid profiles of the participants with and without neuropathy, the researchers found a pattern in the blood lipid profiles 10 years before a person developed neuropathy that showed a signaling dysfunction in a critical way calledB-Oxidation.This route turns lipids into sources of nervous energy and, when deteriorating, the hungry nerves suffer damage, which leads to neuropathy.
"As we learn more about the relationship between serum lipid species and neuropathy, the possibility of directed therapeutic treatment will open, both with medications and lifestyle interventions. Our findings support the concept that fatsNon -saturated healthy are a better source of energy for nerves than highly saturated fats.