Could we see the end of insulin injections?

A study presented at the last meeting of the United States Endocrinology Society opens the door to a future elimination of insulin injections, the only viable treatment so far for type 1 diabetes. It is a therapy based on cells Car cells, that until now have shown tremendous success in leukemia and lymphomas.

These are cells of the immune system, known as T lymphocytes, which are genetically modified to recognize a specific antigen.In the case of hematological cancers, these are cytotoxic T cells, which recognize the tumor cell and destroy it.In diabetes, on the other hand, they focus on inflammation regulators.

Diabetes is an inability to regulate the presence of blood glucose related to a problem for insulin processing.In the case of type 2 diabetes, the most frequent, is almost always the result of the lifestyle (obesity, sedentary lifestyle), which ends up generating insulin resistance, vital to process the glucose present in the blood and that enters theCells

Type 1 diabetes, on the other hand, is an autoimmune disease caused by the destruction of beta cells of the pancreas, insulin producers, through T lymphocytes. It represents between 1% and 5% of all cases of diabetes, about 90,000 people in Spain according to the Spanish Diabetes Society.

It is usually diagnosed at an early age (4.9 years when detected in childhood) and 50% of patients have other associated pathologies, from the alteration of cholesterol levels to retinopathies and nephropathies.Although it is not related to the lifestyle, this does affect the development of the disease.

The team of Argentine Juan Carlos Jaume, professor of Endocrinology at the University of Toledo (Ohio, United States), obtained samples of blood and pancreas of patients who was extracted for some clinical reason (pancreas cancer and pancreatitis).From the blood obtained regulatory T cells, abbreviated as TREGS, which are responsible for regulating or suppressing other cells of the immune system, cultivated and genetically modified them to recognize antigens related to beta cells.

With this modification they introduced another: they associated with the edited T lymphocytes (car tregs) a green fluorescent protein.In this way they could verify if the cells, when they were introduced into the Langerhans islets (the pancreas structures produced by beta cells), survived and proliferated.

The researchers cultivated the pancreatic islets obtained from the human pancreas and combined them with the Car Tregs, which proliferated in the next 72 hours.They were also tested in modified mice to express human type 1 diabetes, showing the same behavior: these lymphocytes, genetically modified, suppressed the response of cytotoxic t lymphocytes that attack the beta cells of the pancreas, regenerating insulin production in the body.

the Cart revolution

"This is the next step of Car cells," explains the president of the Spanish Society of Immunology, Marcos López Hoyos."First have been hematological neoplasms (cancers) and, within a relatively short period, they will be used in solid organ tumors. Autoimmune diseases [such as type 1 diabetes] are the following."

In fact, there are already essays "in early stages" for lupus or multiple sclerosis, and also to avoid rejection in solid organ transplants."The concept of regulatory T cell was fashionable in the 80s between immunologists," he recalls, "but they fell into disuse and they were even proscribed," due to the difficulty in characterizing them molecularly.

Instead, effector T cells, which destroy cells,They were more successful."We can eliminate with cells everything we are eliminating with monoclonal antibodies", therapies that have supposed a step forward in the treatment of cancer in the last two decades.

However, López Hoyos does not believe that, if it exceeds all clinical trials in humans necessary to be approved, this therapy will be used a lot in type 1 diabetes, a well -controlled disease today thanks to innovations in the insulin administration, that make it more and more comfortable for patients.

"It can be a treatment route, above all, in cases considered rebels," says the immunologist.However, the study is another step to demonstrate the potential of a new way to treat numerous diseases.

"This therapy is in its beginnings," he says."The CARs have developed because, methodologically, we have applied many molecular tools and because in the last 20 years we have learned number of immune response mechanisms that we did not know before."Therefore, "in the next 20 years the change will be spectacular."

“López Hoyos does not believe that, if it exceeds all clinical trials in humans necessary to be approved, this therapy will be used a lot in type 1 diabetes, a well -controlled disease currently thanks to innovations in the administration of insulin, which, whichThey make it more and more comfortable for patients. "

Comfortable ??:#

It shows that he does not suffer.

Well ... it is a little wild phrase, it would not give much importance, in the end what is interesting is that they have alternatives to the injected insulin, and if they are viable it is the bomb !!!

Yeah.He says it because it will be a expensive and difficult treatment.And few people can access.

But the current treatment is the opposite of comfortable.

That Majo López Hoyos this ... I'm not me to wish for anyone but I would love to know how he feels like a son or grandson (if he is already in the age of being a grandfather) with type 1 diabetes.

Palurdos as a lord, who will be endocrine, are the kind of doctors that it is better to have far ... I'm sorry for your patients ...

Anyway, that's how the world goes ...

isi said:
that the López Hoyosof being grandfather) with type 1 diabetes.

Palurdos as a lord, who will be endocrine, are the kind of doctors that it is better to have far ... I'm sorry for your patients ...

Anyway, that's how the world goes ...

It is not endocrine, he is a surgeon and immunologic doctor.

The problem more than his, I think is what diabetics and associations, we transmit in the media.That we can do everything and that it is almost a disease, but a life condition.And that with the new devices and insulins everything is fantastic.

Therefore (apart from the interests of pharmaceuticals) they take it so calmly in research.

Throughout the years I hear about many investigations the BGG of Dra Faustman, etcin the US and alvide from methods at least in 20 or 30 years.I tell me that there are many economic interests that could be cured but good.
and the Spanish vaccine against the COVID what happened?Well

I would settle for a good autonomous bomb.That will come.

Don't try it with mice !!Give it to me directly!: D: d

Hopefully one day an important advance will come, but then the great pharmaceutical brand arrives, buy the study and then never knew about the progress ....

For what I have left, I prefer to continue clicking, thanks.

I believe that diabetes is a business for pharmaceuticals and laboratories, it is not interesting that there is a cure ... but whoever says this is like any chronic, easy to carry, that God comes and see it ..... I hope to be able toI get used to her, but I am getting uphill, sometimes, I come to think that I need a psychologist.This needs a dedication continues and full on a day -to -day basis, and even sometimes putting all the efforts, the expected results are not achieved.

This is not easy, Cassie.In September I will turn a year since the diagnosis and I still have moments of do I have diabetes?I went from being healthy as an apple to being chronic sick.Thus, without more.
I have always cared for my health, my nutrition, I have practiced sports, I protect myself from the Sun, I do not smoke, I do not stop and have touched this little gift.But I am clear that regretting for it is useless (well, sometimes, a little while ...).
So it's time to get ahead, study a lot, listen to those who know and those who have experience and learn.Know you, see your reactions to this or that food, in this or that situation.Being indulgent, we are going to make a lot of mistake, each error is not a failure but a fact for our personal knowledge when handling this disease.
You are right, the dedication is 24/7 there is no rest or vacation but you will be integrating it in your day to day, what a remedy.As for the psychologist, it seems to me a good idea, if you feel very overwhelmed and do not get for yourself to reach serenity and lift your mood, go to therapy can be a help.
You will see that this forum is very enriching, we all go through the same and something can be learned from each one.And you feel heard and understood, which is very comforting.

VERTEX already has permission to continue with the essays:
July 5: Link
June 6: Link

I hold on to a burning nail ...

palomilla said:
vertex already has permission to continue with the trials:
July 5: Link
June 6: Link

I grab a burning nail ...

That has been working for 30 years.Islet transplant with immunosuppressants.

fer said:
@Fer said:

A study presented at the last meeting of the United States Endocrinology Society opens the door to a future elimination of insulin injections, the only viable treatment so far for type 1 diabetes. It is a therapy based on Car cells, which until now have shown tremendous success in leukemia and lymphomas.

These are cells of the immune system, known as T lymphocytes, which are genetically modified to recognize a specific antigen.In the case of hematological cancers, these are cytotoxic T cells, which recognize the tumor cell and destroy it.In diabetes, on the other hand, they focus on inflammation regulators.

Diabetes is an inability to regulate the presence of blood glucose related to a problem for insulin processing.In the case of type 2 diabetes, the most frequent, is almost always the result of lifestyle (obesity, sedentary lifestyle), which ends up generating insulin resistance, vital to process the glucose present in the blood and that enters the cells.

Type 1 diabetes, on the other hand, is an autoimmune disease caused by the destruction of beta cells of the pancreas, insulin producers, through T lymphocytes. It represents between 1% and 5% of all cases of diabetes, about 90,000 people in Spain according to the Spanish Diabetes Society.

It is usually diagnosed at an early age (4.9 years when detected in childhood) and 50% of patients have other associated pathologies, from the alteration of cholesterol levels to retinopathies and nephropathies.Although it is not related to the lifestyle, this does affect the development of the disease.

The team of Argentine Juan Carlos Jaume, professor of Endocrinology at the University of Toledo (Ohio, United States), obtained samples of blood and pancreas of patients who was extracted for some clinical reason (pancreas cancer and pancreatitis).From the blood obtained regulatory T cells, abbreviated as TREGS, which are responsible for regulating or suppressing other cells of the immune system, cultivated and genetically modified them to recognize antigens related to beta cells.

With this modification they introduced another: they associated with the edited T lymphocytes (car tregs) a green fluorescent protein.In this way they could verify if the cells, when they were introduced into the Langerhans islets (the pancreas structures produced by beta cells), survived and proliferated.

The researchers cultivated the pancreatic islets obtained from the human pancreas and combined them with the Car Tregs, which proliferated in the next 72 hours.They were also tested in modified mice to express human type 1 diabetes, showing the same behavior: these lymphocytes, genetically modified, suppressed the response of cytotoxic t lymphocytes that attack the beta cells of the pancreas, regenerating insulin production in the body.

The Cart revolution

"This is the next step of Car cells," explains the president of the Spanish Society of Immunology, Marcos López Hoyos."First have been hematological neoplasms (cancers) and, within a relatively short period, they will be used in solid organ tumors. Autoimmune diseases [such as type 1 diabetes] are the following."

In fact, there are already essays "in early stages" for lupus or multiple sclerosis, and also to avoid rejection in solid organ transplants."The concept of regulatory T cell was fashionable in the 80s between immunologists," he recalls, "but they fell into disuse and they were even proscribed," due to the difficulty in characterizing them molecularly.

Instead, effector T cells, which destroy cells, were more successful."We can eliminate with cells everything we are eliminating with monoclonal antibodies", therapies that have supposed a step forward in the treatment of cancer in the last two decades.

However, López Hoyos does not believe that, if it exceeds all clinical trials in humans necessary to be approved, this therapy will be used a lot in type 1 diabetes, a well -controlled disease currently thanks to innovations in the administration of insulin, which make it more and more comfortable for patients.

"It can be a treatment route, above all, in cases considered rebels," says the immunologist.However, the study is another step to demonstrate the potential of a new way to treat numerous diseases.

"This therapy is in its beginnings," he says."The CARs have developed because, methodologically, we have applied many molecular tools and because in the last 20 years we have learned number of immune response mechanisms that we did not know before."Therefore, "in the next 20 years the change will be spectacular."

I already made the idea that I will die with diabetes, they already cheated me and sold me too much smoke.From the 1st minute that I started with diabetes, at that time I was admitted to the only center I think there was nationwide in relation to diabetes in Infanta Mercedes in Madrid.There with only 12 years I remember my first contact with an endocrine and his prayers "that he was calm that he was investigating a lot on the subject and in 5 or 10 years you have there are two a cure" damn ignorance with title and gown, since it has rained a lot since then without having changed the method.Moreover, the number of diabetics has multiplied and remains on exponential scale every year, while the supposed cure or semi -public that is publicly in science, web, RRSS, each year magazines never materialize, illusive studies are announced of which it does not know more again.This is like the famous phrase of Jose Mota "No today, tomorrow."I usually question, if the same laboratory or pharmaceutical researchers who earn millions of euros with diabetics are really interested in getting something that makes them run out of customers and those benefits.That there have been improvements, it is undoubtedly, for better comfort, but I do not believe that they have been exponential to the industrial, technological and scientific evolution, an eye this is a my opinion, that there will be who is very satisfied with the progress, but for me after so much traveled and comparing with other sectors it seems insufficient.Whoever wants to live in that mirage, is free, but eye with being sold happily this context because it is played with despair of the debutants and that can lead to consequences.

[[ERROR-TRANS]]@LuVi entiendo perfectamente lo que sientes y la frustración que transmites. A muchos nos prometieron lo mismo cuando debutamos, y es verdad que las expectativas que nos dieron en su día sobre la "cura" no se han cumplido. Eso duele, sobre todo cuando uno ha puesto ilusión en cada titular que hablaba de avances revolucionarios que luego nunca llegan a nada.

I agree with you that it is not fair to sell smoke, especially to newly diagnosed people, because it can generate false hopes and enormous disappointment.The reality is that, as you say, the cure is not yet here.

That said, I also believe that it is important to assess that, even if we do not have a cure, there have been advances that have changed our day to day: faster insulins, sensors, bombs, hybrid algorithms ... They do not cure us, but allow us to live with more freedom and security than a few years ago.

Your reflection is very necessary, because you remember that you have to talk with responsibility and feet on the ground.And at the same time, I think we also have to support ourselves between us so as not to fall into total despair: living with diabetes is hard, but you can live well and with quality of life, especially if we share experiences, learning and accompany ourselves as a community.

Thank you for saying what many have ever thought.

@Fer said:

@UviI perfectly understand what you feel and the frustration you transmit.Many promised us the same when we debuted, and it is true that the expectations they gave us in their "cure" have not been fulfilled.That hurts, especially when one has placed enthusiasm in each holder who talked about revolutionary advances that they never get to anything.

I agree with you that it is not fair to sell smoke, especially to newly diagnosed people, because it can generate false hopes and enormous disappointment.The reality is that, as you say, the cure is not yet here.

That said, I also believe that it is important to assess that, even if we do not have a cure, there have been advances that have changed our day to day: faster insulins, sensors, bombs, hybrid algorithms ... They do not cure us, but allow us to live with more freedom and security than a few years ago.

Your reflection is very necessary, because you remember that you have to talk with responsibility and feet on the ground.And at the same time, I think we also have to support ourselves between us so as not to fall into total despair: living with diabetes is hard, but you can live well and with quality of life, especially if we share experiences, learning and accompany ourselves as a community.

Thank you for saying what many have ever thought.

Indeed there have been changes, improvements and advances ... I do not deny it and I do not despise it, but for me (it is personal opinion) I will not use the word deficient, but if I have that feeling of being "halfway."For example, the marketing of the pen, was a relief to the use of that syringe and the effect it caused on people who saw you with one, but its format is the same as more than 20 years ago, I mean that it could have been improved.The bombs for all those people with physiological difficulties to maintain good control was a salvation as well as for those who found it complicated to agree to bring insulin and when it touches me one or the other.With all this, they continue to work with conventional batteries and use the Bluetooth (something little sure and easy to hack) and the problem of catheter folds.I think the pumps can improve in both aspects.The sensors ... Well, here on the one hand, the SS subsidized them has been a very large benefit, but it has also deprived us of the competition that could have been and the possible improvements, since Abbott, having the monopoly is accommodated in a product from which he has been taking versions such as innovation, when it really could be done with his first version.

As for the community, support .. Discrepo, people with diabetes are individual, encrypted and hidden, among ourselves.You cross with someone who carries a sensor and we are unable to approach and state that we also have diabetes, it is as if we consider ourselves different people, we only open and share our disease from the anonymity of sites like this.Proof of this do you have it in the events section of this same forum, how many initiatives of stays, exits, meetings, cinemas, etc. have been scheduled?None.

How many RRSS Telegram, WhatsApp, Facebook are about groups of people from a certain autonomous community with diabetes?

That is reality.