{'en': 'Everything you should know about GLP-1 and GIP hormones', 'es': 'Todo lo que debes saber sobre las hormonas incretinas GLP-1 y GIP'} Image

Everything you should know about GLP-1 and GIP hormones

juanluis's profile photo   02/21/2019 2:40 p.m.

The incretins are hormones secreted by intestines in response to a meal, which stimulate the production of insulin and inhibit the glucagon .Therefore, they play an important role in the control of blood glucose (blood glucose).

The main incredine hormones are: the LPG-1 (peptide similar to glucagon-1, for its acronym in English) and the gip (glucose-dependent insulinotropic peptide).



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Physiological aspects of incredines


Intestin-pancreas axis and glycemia control


Incredines are hormones synthesized by endocrine cells of the intestines, and that are released after the intake of a meal.Its main physiological effect is to increase the production of insulin by the beta cells of the pancreas.The LPG-1, in addition, inhibits the release of glucagon (Rev Med mediaInst Mex Sure SOC) for the alpha cells of the same organ.

An important characteristic of these substances is that they only act when blood glucose is high.Its main effect is, therefore, to prevent postprandial blood glucose (after meals) to rise too much.



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What causes increased incredine secretion?

The hormones incredine are secreted and released towards the bloodstream by the presence of food, especially carbohydrates, in the intestines.This phenomenon is observed to a lesser extent after the administration of glucose by intravenous route.

How do incredines act?

After being released by the intestines to the bloodstream, the incredines reach all body tissues, producing several effects:


  1.In the pancreas, both GLP-1 and GIP stimulate beta cells to increase insulin production.The LPG-1 also inhibits glucagon secretion.
2. In the stomach, the GLP-1 slows gastric emptying, which decreases postprandial blood glucose and appetite.
3. In the brain, the LPG-1 produces central decrease in appetite

Inactivation of incredine hormones


The activity of incredine hormones in the tissues is short-lived, since they are neutralized by an enzyme called dpp-4 ( dipeptidil peptidase 4 ).


INCRETINE EFFECT


The incredine effect refers to the greater insulin secretion observed after the administration of glucose by the oral route compared to that observed after the infusion of the same amount of glucose by wayendovenous (J of the soc for biomedical diabetes res) .


In healthy people, the incredin effect represents until 70% of insulin secretion in response to a meal.

Incredines in type 2 diabetes


Patients with type 2 diabetes have a Decreased increasing effect .This translates into a decrease in insulin release by the beta cells of the pancreas and an increase in glucagon by alpha cells, which contributes to the postprandial hyperglycemia .This is the first observable biochemical alteration in type 2 diabetes. Then the fasting hyperglycemia ensures .


Conclusion


As we have seen in this article, incredine hormones play an important role in the proper functioning of alpha and beta cells of the pancreas, producers of glucagon and insulin hormones, which in turn are responsible for maintaining glucose levelsblood within physiological limits.


These properties have been used by the pharmaceutical industry, which in recent years has introduced effective medications for both the treatment of obesity and diabetes .

juanluis's profile photo
juanluis
02/21/2019 2:40 p.m.

  

Hello Juanluis, they give it to me, although I am Lada diabetes next to Lantus and Novorapid and I have a 0.50 ng peptide.

Clau's profile photo
Clau
02/25/2019 5:51 p.m.

Diabetes Lada 1 desde 2018
60
Toujeo 16 U
Fiasp según conteo de CH
HG 6.5%
Freestyle

  

Good night, Clau.Your peptide C levels are consistent with the diagnosis of Lada.And yes, incredine-based therapies (both DPP-4 inhibitors and the analogues of LPG-1) have shown to be effective in their treatment.I think it is recommended that you also put insulin.Thanks for your contribution

juanluis's profile photo
juanluis
02/25/2019 9:26 p.m.

  

If Juanluis, I use both every day.Thanks for your answer.

Clau's profile photo
Clau
02/26/2019 1:27 a.m.

Diabetes Lada 1 desde 2018
60
Toujeo 16 U
Fiasp según conteo de CH
HG 6.5%
Freestyle

  

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