Researchers at the Biomedical Research Center of Diabetes and Metabolic Diseases (CIBERDEM) at the Health Research Institute of the Jiménez Díaz Foundation University Hospital (IIS-FJD) and the Autonomous University of Madrid (UAM) have described a new therapeutic approach forCombat inflammation and oxidative stress in diabetes damaged tissues and thus stop the progression of chronic complications associated with this disease, as reported in a note.
The investigating team, led by Jesús Egado and Carmen Gómez-Guerrero, has demonstrated experimentally that the therapy based on the family protein family effectively reduces the presence of free radicals in the arteries and the kidney, two very susceptible territories ofsuffer damage from high glucose levels and where the complications of diabetes are presented in greater proportion.
The study has been published in the Laboratory Investigation magazine and the researchers Laura López-Sanz, Susana Bernal, Carlota Recio, Iolanda Lázaro, Ainhoa Oguiza, Luna Jiménez-Castilla and Ana Melgar have also participated in it.
oxidative stress paper in the complications of diabetes
Diabetes is a disease that is reaching epidemic proportions and is an important cause of death throughout the world.It is estimated that, at present, more than 400 million people in the world suffer from diabetes (more than 5 million in Spain), many of which are still unrelated.The great socio -health impact of this disease is due, in part, to the importance of its chronic complications, since high levels of blood glucose deteriorate in the long term the functionality of different tissues such as kidney, eye, nerves and cardiovascular system.
In fact, atherosclerosis is a frequent cardiovascular complication caused by diabetes and the main responsible for the morbidity and mortality of patients with type 1 diabetes and 2. renal affectation (diabetic nephropathy) is present in approximately one third of patients with patients withDiabetes and is the main cause of entry into dialysis and transplant programs, in addition to increasing the risk of cardiovascular disease.
Oxidative stress is a mechanism involved in the development and progression of chronic diabetes complications, including atherosclerosis and diabetic nephropathy.Oxidative stress is produced by an imbalance in the redox balance of the cell that can be due to excessive production of free radicals by pro-oxidant systems, and the deterioration of antioxidant defense systems.This imbalance is the cause of oxidative alterations in different macromolecules, such as DNA, proteins and lipids, which negatively affect cell functionality.