Spanish researchers identify biomarkers that betray the "false thin."These are people who, despite having a normal weight for their stature, have a high percentage of visceral fat, greater risk of diabetes and suffering from cardiovascular disease.
A study by the University of Navarra clinic ensures that three out of ten thin are, in fact, obese.The investigation valued more than 6000 individuals with the aim of detecting the degree of BMI error by diagnosing obesity, and finally it was concluded that 29% of the people who according to the indicator are normal in weight, actually present, obesity or theThat is the same, an excess of fat in your body.
In relation to this issue, a research group in Nutrigenomics and Obesity of the University of the Balearic Islands, led by Andreu Palou and Paula Oliver, has discovered early blood biomarkers that allow identifying the health risks associated with the phenotype known as Normopese obesity, that is, the so -called false thin ones.
But who are the false thin ones?
Experts say that they are people who have a normal weight of according to their stature, but that have characteristics related to obesity, such as deposition of visceral fat, and a greater risk of suffering from type 2 diabetes mellitus and cardiovascular disease.
In this sense, experts have reported that this syndrome, known in scientific literature as Normopese Obesity, is associated with the intake of unbalanced diets, rich in fat or with excess of simple sugars and a decrease in physical activity, and constitutesA serious public health problem.
Specifically, researchers have demonstrated in rodents that this phenotype is associated with an anomalous fat deposition in the liver, even in the absence of obesity, and without increasing the blood levels of classic markers such as cholesterol and triglycerides that can serveas a alarm signal.
In addition, studies have shown for the first time that the intake of an unbalanced diet rich in fat increases the expression of a protein, the KRT23, in the liver of animals with false phenotype thin.This protein has been described as a marker of liver disease in people.
Similarly, they have identified the usefulness of gene expression analysis in a fraction of easily obtained blood cells, peripheral blood mononuclear cells (PBMC), to monitor the health deviations that occur in animals with animals with false phenotypeslim.
Following this work, in an article recently published in Food and Nutrition Research, the group proposes the analysis of the expression of the CPT1A gene, whose increase in blood cells is predictive of the future development of alterations such as insulin resistance and,,Particularly, fat deposition in the liver.