Type 1 diabetes occurs when the body produces little or no insulin, the hormone that plays a crucial role in the transport of blood sugar to body cells, and usually affects people at an early age.In general, it develops when the body's own immune system attacks the pancreas and prevents the gland from producing insulin, so it is an autoimmune disease.
People with type 1 diabetes show inflammation in the digestive tract and intestinal bacteria, a pattern that differs from people who do not suffer diabetes or those who have celiac disease, according to a new study published in 'Journal of Clinical Endocrinology & AMP;Metabolism ', a magazine of endocrine society.
"Our findings indicate that people with type 1 diabetes have an inflammatory firm and a microbiome that differ from what we see in people who do not have diabetes or even those with other autoimmune pathologies, such as celiac disease," summarizes the main author of the main author of the main author of the main author of the main author of theStudy, Lorenzo Piemonti, of the Diabetes Research Institute at the San Raffee Hospital in Milan, Italy."Some researchers have theorized that the intestine can contribute to the development of type 1 diabetes, so it is important to understand how the disease affects the digestive and microbiome system," he adds.
more inflammation in the mucous membrane of the intestine
The study examined the microbiome of 54 individuals who underwent endoscopies and biopsies of the first part of the small intestine, known as the duodenum, at the San Raffee Hospital between 2009 and 2015. The participants were recruited by performing a diagnosis procedure to diagnoseA gastrointestinal disorder or voluntarily offered to participate in the study.
This approach allowed researchers to directly evaluate the gastrointestinal tract and bacteria, unlike the analysis that are based on stool samples to do the investigation.The tissue analysis by endoscopy produced high resolution snapshots of the most internal layer of the gastrointestinal tract.
Individuals with type 1 diabetes showed significantly more signs of inflammation of the mucous membrane of the intestine linked to ten specific genes than participants who had celiac disease and healthy control subjects.Participants with type 1 diabetes also showed a different combination of intestinal bacteria that was different from the other two groups.
"We do not know if the effect of type 1 diabetes on the intestine is caused by the body's own attack to the pancreas,"unique gastrointestinal of people with type 1 diabetes ".