{'en': 'They find a possible cause of the immune attacks of type 1 diabetes', 'es': 'Hallan una posible causa de los ataques inmunes de la diabetes tipo 1'} Image

They find a possible cause of the immune attacks of type 1 diabetes

fer's profile photo   11/25/2016 12:23 p.m.

The discovery has been the work of a team of researchers from the Federal Polytechnic School of Lausana (EPFL), in Lausana, Switzerland.

Type 1 diabetes occurs when immune cells attack the pancreas.Now, researchers from the Federal Polytechnic School of Lausana (EPFL), in Lausana, Switzerland, have discovered what this attack can trigger, a finding that can open new paths for disease treatments.

It is the rarest but more aggressive way of diabetes, which usually affects children and adolescents and in which the patient's immune cells themselves begin to attack the pancreas cells that produce insulin, eventually eliminating their production in the body.Immune cells direct certain proteins within insulin producing cells.

However, it is not clear how it really happens.EPFL experts have discovered that the immune attack in type 1 diabetes can be triggered by the release of proteins of the pancreas itself, as well as the package in which they are found.The work, which has significant implications for therapeutic strategies, is detailed in an article published in diabetes.

Diabetes is a disease in which the body produces inappropriate amounts or does not produce insulin hormone, which regulates blood sugar levels.A group of cells in the pancreas called beta cells are responsible for manufacturing insulin.In type 1 diabetes, the patient's immune cells specifically attack beta cells, thus interrupting insulin production, but it is not known exactly what that first attack of immune cells attacks.

Researchers from the EPFL Bioengineering Institute, led by Steinunn Baekkeskov, have discovered that pancreatic beta cells secrete proteins that are attacked by the immune system.But it is not just the proteins that cause problems;but also its packaging.

The exosome, a possible culprit

This container comes in the form of small vesicles called exosomes, which are secreted by all types of cells to distribute several molecules with different functions.Previous studies have shown that exosomes can also activate the immune system.Based on this, the EPFL researchers examined the exosomes of human and animal pancreatic cells.

The results of their analysis showed that the pancreatic beta cells of rats and humans release three proteins known for being linked to type 1 diabetes and, in fact, they are used by doctors to diagnose their appearance in people.

They could also have discovered why the immune attack against the pancreas begins: when beta cells produced by insulin were exposed to stress, they released large amounts of exosomes, which also "decorated" with proteins that activate immune cells.These powerful inflammatory proteins may be involved in induction of autoimmunity in pathology.

fer's profile photo
fer
11/25/2016 12:23 p.m.

@fer - Diabetes Tipo 1 desde 1.998 | FreeStyle Libre 3 | Ypsomed mylife YpsoPump + CamAPS FX | Sin complicaciones. Miembro del equipo de moderación del foro.
Co-Autor de Vivir con Diabetes: El poder de la comunidad online, parte de los ingresos se destinan a financiar el foro de diabetes y mantener la comunidad online activa.

  

Well that.Stress.As we already intuit.
Let them stop milks and find something effective on a stuffing time.

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aaandres
11/25/2016 3:07 p.m.

Padre de Andrés, 17 años. Debut: septiembre de 2011.
Levemir (30ud. mañana y 24ud. noche) y Novorapid (en desayuno, comida, merienda y cena 40ud aprox - 24HC/día).
Medidor continuo DEXCOM G4 desde julio 2014
Hemo: 6.2 (Sept. 2013), 7.0 (Dic. 2013), 6.9 (Marzo 2014), 6,6 (Junio 2014), 6,7 (Sept. 2014), 7,0 (Dic. 2014), 7,7 (Mar 2015), 6,9 (Jul. 2015), 7,0 (Sept 2015), 7,4 (Dic 2015), 6,8 (Mar 2016), 6,6 (Julio 2016), 6,8 (Octubre2016)... 7,0 (Mar 2018)

  

And viruses, in young children a virus usually triggers it.That is why it is already taking a vaccine that avoids it.

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Regina
11/25/2016 4:48 p.m.

Hija de 35 años , diabética desde los 5. Glico: normalmente de 6 , pero 6,7 la última ( 6,2 marcaba el Free)
Fiasp: 4- 4- 3 Toujeo: 20

  

But how many possible causes are they already? They have no idea of ​​anything.
That seek solutions in addition to possible causes.

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ajd
11/25/2016 4:49 p.m.
No signature configured, update it from user's profile.

  

ajd said:
But how many possible causes are they already?, they have no idea of ​​anything.
That seek solutions in addition to possible causes.

Every year they get a new possible cause, thus scientists can publish new articles, which really matters to them.Looking for a cure and such.

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Sherpa41
11/25/2016 6:53 p.m.

En 1922 descubrieron la insulina, en 1930 la insulina lenta. ¿Que c*** han hecho desde entonces?

  

Well.... a possible more cause ... but let's see if they take away our needles and give us something friendlier to live

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Ruthbia
11/25/2016 8:01 p.m.

Lada enero 2015.
Uso Toujeo y Novorapid.

  

I had already seen the news, I chose not to put it in the forum because things are taken for what is not and there are false hopes.

Our immune system failure is very complicated to solve, and to know how to fix something it is interesting to know why it fails.
At the moment they almost have no idea of ​​the mechanisms involved so this can be a good step in the right direction.
But they are just that, small steps, on a long road.

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Artorias
11/25/2016 11:01 p.m.
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They still have no stab Idea ...

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fjf
11/27/2016 3:03 p.m.
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26th Congress of the Spanish Diabetes Society (SED)
Researchers propose a paradigm shift in DM1 pathogenesis.
They suggest that immune system alterations could be a consequence and no origin of the pathology.
Link Pag 16.
If they do not find the cause of DM1, except the cure.

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solaria
11/28/2016 8:08 p.m.

Debut 46 â- 2012. DM1. Celiaquía e intolerancia lactosa. Anemia perniciosa.
MiniMed 640g + SmartGuard.

  

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