Progress in the development of a type 1 diabetes vaccine

fer's profile photo   03/31/2016 10:22 a.m.

Helmholtz Diabetes Center scientists manage to generate human regulatory cells with the ability to inhibit autoreactive T lymphocytes.

A study published in the journal Nature Communications shows that it is possible to induce regulators T lymphocytes that prevent autoimmunity against pancreatic islets.Using humanized mice with human hematopoietic stem cells and immunized with mimotopes of insulin, scientists have managed to generate Foxp3+ (TREG) lymphocytes, a population known for their ability to regulate the function of other lymphocytes and prevent autoimmunity.

The TREG produced by this method are stable, present all the characteristic markers of this lymphocyte population and suppress with high efficiency the activation of the authentive effectors T lymphocytes.In young animals, immunization with low doses of mimotopes completely prevented the development of type 1 diabetes.

The mimotopes are peptide fragments that mimic the three -dimensional structure of the epitopes, or antigen fragments, which do not present homology with the sequence of these.Previous studies had already indicated that mimotopes are more efficient in induction of immune tolerance than epitopes.

Although the development of the specific autoantigen vaccination is still in its childhood, the new study represents a great leap forward in achieving precision therapy for children at risk of type 1 diabetes.

fer's profile photo
fer
03/31/2016 10:22 a.m.

@fer - Diabetes Tipo 1 desde 1.998 | FreeStyle Libre 3 | Ypsomed mylife YpsoPump + CamAPS FX | Sin complicaciones. Miembro del equipo de moderación del foro.
Co-Autor de Vivir con Diabetes: El poder de la comunidad online, parte de los ingresos se destinan a financiar el foro de diabetes y mantener la comunidad online activa.

  

I expected it

Regina's profile photo
Regina
03/31/2016 12:58 p.m.

Hija de 35 años , diabética desde los 5. Glico: normalmente de 6 , pero 6,7 la última ( 6,2 marcaba el Free)
Fiasp: 4- 4- 3 Toujeo: 20

  

Join the Discussion!

To participate in this thread, please register or log in.