Researchers at the Institute of Biomedical Research August Pi I Sunyer (IDIBAPS) of the Hospital Clínic de Barcelona have discovered that alterations in a specific type of hypothalamus neurons are related to the development of type 2 diabetes, regardless of body weight.
The research, which is published on the cover Cell Reports, has described a molecular mechanism that relates the development of type 2 diabetes with the incorrect functioning of a cell organelle, the endoplasmic reticulum, in a type of neurons called POMC that are found inThe hypothalamus.
According to the research director, Marce Claret, who works in the Diabetes and Obesity Laboratory of IDIBAPS, "the key is the processing of Alfa-Msh, a neuropeptide that occurs in this type of neurons, which when it is alteredthat increases the amount of glucose produced by the liver ".
"It was known that stress was related to the resistance of the hypothalamus and appetite neurons and now we have gone further," Claret said.