{'en': 'How does metformin act in the brain?', 'es': '¿Cómo actúa la metformina en el cerebro?'} Image

How does metformin act in the brain?

  
fer
07/31/2025 9:41 a.m.

If you have type 2 diabetes and metformin, surely you know it is one of the most used medications to control glucose.But did you know that until now it was not fully known how it worked?

A new study published in Science Advances has discovered something that can change the way we understand this medicine: metformin not only acts in the liver and intestine, it also does so in the brain!Specifically in an area called ventromedial hypothalamus, where glucose regulates through a protein called rap1.

This is a radical turn.For years it was thought that its action was basically liver, but now we know that even small amounts of metformin in the brain can reduce blood glucose significantly.


Why does this matter?

👉 Because the door opens to more precise, effective and less dose treatments.

👉 Because he explains why, despite taking 60 years in use, metformin continues to surprise.

👉 Because it could be used in the future to design drugs that act directly on the brain, and not only on peripheral organs.

👉 And because the theory is reinforced that metformin could also protect the brain against aging.


For us, as people with diabetes, this is hopeful.It reminds us that science continues to progress, that there is still much to discover, and that what we take every day is not only a routine, but part of a field that constantly evolves to improve our life.


Do you also take metformin?

Did you expect this discovery?

We read you in the comments!👇

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semanu
08/12/2025 10:45 a.m.

This topic is very interesting, thank you very much for sharing it

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_Tacker_
08/16/2025 5:33 p.m.

Good, they just prescribed metformin and I am DM1, in theory it is sent to me by the endocrine to help the insulin resistance that I supposedly have .....

I have not noticed anything more than a month, but as long as I have as many advantages as you comment I will continue with her.I try to prick the least amount of insulin possible and that makes it a lot around 170 .....

I will keep looking at how it is doing, thanks for the contributions.

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