{'en': 'An insulin pill to treat diabetes', 'es': 'Una píldora de insulina para tratar la diabetes'} Image

An insulin pill to treat diabetes

fer's profile photo   11/25/2015 9:51 a.m.

Many people in the world suffer diabetes, diagnosed or not.In the United States alone, the estimated figure is more than 29 million people.Many of them require regular insulin injections.

The ideal would be to administer it orally, for example in a pill.Although oral medications to help the body produce insulin are available for a long time, a pill that supplies insulin remains a very sought after target of diabetes medicine.

The main obstacle to its development has been to take the medication through the hostile proteolytic barrier of the stomach and intestine, without destroying the protein itself.

An insulin pill that is being developed by Samir Mitragotri and Amritallow them to do without the annoying punctures.

The key innovation of the new pill is a combination of enteric coating of the carrier capsule and mucoadherent polymer patches loaded with insulin that were optimized by Banerjee as part of their work during the investigation.

Amrita Banerjee, holding the enteric capsule with insulin -loaded patches.

The new pill has demonstrated its resistance to the action of stomach acids thanks to the protection of the enteric coating of the capsule and its effectiveness by releasing its load in the small intestine.

There, the capsule opens to release the patches that adhere to the intestinal wall, avoiding the access of proteolytic enzymes to insulin and, with the help of a permeation amplifier, depositing it in such a way that it can pass to the blood.

The new drug supply technology could also be applied to many other therapies.

fer's profile photo
fer
11/25/2015 9:51 a.m.

@fer - Diabetes Tipo 1 desde 1.998 | FreeStyle Libre 3 | Ypsomed mylife YpsoPump + CamAPS FX | Sin complicaciones. Miembro del equipo de moderación del foro.
Co-Autor de Vivir con Diabetes: El poder de la comunidad online, parte de los ingresos se destinan a financiar el foro de diabetes y mantener la comunidad online activa.

  

But the pills are all the same, and we all carry amounts of different insulin, I do not see that future.

aranzazuleg's profile photo
aranzazuleg
11/25/2015 12:38 p.m.
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And I can't imagine young children swallowing those huge capsules.Come on, I would swallow them without being able to leave them or anything.

Sherpa41's profile photo
Sherpa41
11/25/2015 1:20 p.m.

En 1922 descubrieron la insulina, en 1930 la insulina lenta. ¿Que c*** han hecho desde entonces?

  

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